DEVELOPMENT OF A FILLER-BINDER DISINTEGRANT FOR DIRECT COMPRESSION TABLETING BY CO-PROCESSING MICROCRYSTALLINE CELLULOSE AND CROSPOVIDONE
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 3000
ABSTRACT
The aim of the study was to improve the disintegration functionality of microcrystalline cellulose (MCC) as a direct compression excipient in tablet formulation by coprocessing MCCwith crospovidone (CPV), a superdisintegrant. Design of Experiment (DoE) approach was adopted to optimize the composition of the co-processed excipient (CPE). The optimized CPE containing MCC (99 %) and CPV (1 %) was prepared using wet massing technique. Solid-state properties of CPE were characterized in comparison to MCC and CPV using optical and scanning electron microscopy (SEM), Powder XRay Diffraction (PXRD), Differential Scanning Calorimetry (DSC) and Fourier Transform Infra-red spectroscopy (FT-IR). Powder properties such as flowability, compressibility, moisture sorption capacity, moisture content, dilution potential and lubricant sensitivity ratio (LSR) were also evaluated using standard techniques. Compaction studies were carried out using Heckel and Kawakita equations as well as compressibility-tabletability-compactibility (CTC) profiling. Tablets were formulated by direct compression incorporating metronidazole as the model drug and properties of tablets evaluated. The study revealed an increase in particle size which enhanced the flowability of MCC as a co-processed excipient. Solid state properties of CPE revealed a material consisting of irregular shaped fibrous particles characterized by a rough texture. PXRD and DSC scans presented a material that is semi-crystalline in nature. Moisture content and moisture sorption capacity of MCC was found to decrease as a result of co-processing. The extent of plastic deformation was reduced in MCC when co-processed with CPV and this translated to a reduction in the tabletability of MCC. Tablets formulated with CPE disintegrated at 11.48mins as compared to MCC tablets that disintegrated at 26.88 mins and this was reflected in the in vitro drug release profile with CPE tablets viii attaining maximum drug release at 20mins compared to MCC tablets that attained maximum drug release at 60mins. Thus, the functionality of MCC as a disintegrating filler binder for direct compression tableting was improved by co-processing with crospovidone.
Related Project Materials
THE CAUSES, EFFECTS AND SOLUTION TO EXAMINATION MALPRACTICE IN SECONDARY SCHOOLS (A CASE STUDY OF ILAJE LOCAL GOVERNMENT AREA)
ABSTRACT
This research project work aims the causes, effect and remedy to examination malpractice amongst secondary scho...
PRODUCTION OF HIGH QUALITY FOAM
ABSTRACT
The production of high quality foam was carried. The actualization of the production of polyurethane (fib...
AN EVALUATION OF DRACUNCULIASIS AND THE INTERVENTION STRATEGIES ADOPTED FOR ITS ERADICATION IN BORNO STATE, NIGERIA
ABSTRACT
Interventions adopted for the eradication of dracunculiasis in Borno State were evaluated between July 2003 and June 2004 to ass...
AN APPRAISAL OF ACCOUNTING FOR DISTRESSED ASSET FUNDS AND WORKOUTS
Abstract: AN APPRAISAL OF ACCOUNTING FOR DISTRESSED ASSET FUNDS AND WORKOUTS
This study aims to: (1) examine the accounting practices for...
STRATEGIES FOR PROMOTING CREATIVITY AND IMAGINATION IN EARLY CHILDHOOD EDUCATION (ECE) SETTINGS IN NIGERIA
Abstract: This study explores strategies for promoting creativity and imagination in early childhood educati...
THE INFLUENCE OF TECHNOLOGICAL PROFICIENCY ON ADMINISTRATIVE EFFICIENCY
THE INFLUENCE OF TECHNOLOGICAL PROFICIENCY ON ADMINISTRATIVE EFFICIENCY
Abstract: This...
FOOD SECURITY AND NATIONAL DEVELOPMENT IMPLICATION FOR HOME ECONOMICS EDUCATION
ABSTRACT
This research work explored the concept of food security and its relationship to national deve...
IMPACT OF SOCIAL MEDIA IN MANAGING BRAND REPUTATION IN CRISES
Abstract
The research provides a conceptual and theoretical appraisal of the impact of social media in managing. As soc...
GENETIC VARIABILITY STUDIES OF SOME NIGERIAN SOYBEAN (GLYCINEMAX(L) MERRIL) ACCESSIONS
ABSTRACT
Soybean is a very important leguminous seed crop; known for its highly valued proteinandoilowingto its use in food, feed and ind...
AN ASSESSMENT OF NEWSPAPERS IN REPORTING DOMESTIC VIOLENCE IN IMO STATE
Background of the study
Domestic and sexual violence are shown in the media in such a way that the publ...
